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SMH’s Published Research on Gastrointestinal Cancer

Sarasota Memorial’s nationally recognized Cancer Research Department has published numerous cancer-related studies in respected medical journals. Below is a sampling of our team’s recent published research related to gastrointestinal cancers.

For information on current cancer trials, visit our Cancer Clinical Trials webpage. To learn about other medical trials, email or call 941-917-2225.

Outcomes of Locoregional Therapy for Metastatic Gastric Cancer

Chemotherapy is the standard of care for treatment of metastatic gastric cancer. The purpose of this study was to compare overall survival rates of metastatic gastric cancer patients who received chemotherapy to determine whether there is a survival benefit associated with surgery and radiation therapy. Results showed that surgery was associated with an overall survival benefit. Patients receiving preoperative, but not postoperative, radiation therapy had better survival compared to those who only had surgery. [Journal of Clinical Oncology 35, 2017 (suppl 4S; abstract 143)]

Outcomes of Adjuvant Chemotherapy after Neoadjuvant Chemoradiotherapy for Esophageal Cancer

The use of adjuvant chemotherapy after neoadjuvant chemoradiation and surgery for esophageal cancer is debatable. This study aimed to determine whether adjuvant chemotherapy is associated with an overall survival benefit following neoadjuvant chemoradiation. Results showed a survival benefit favoring adjuvant chemotherapy for lymph node positive patients. [Journal of Clinical Oncology 35, 2017 (suppl 4S; abstract 92)]

Upfront Surgery, Neoadjuvant and Definitive Chemoradiation for Clinical T2N0 Esophageal Adenocarcinoma: A Propensity Score Matched Analysis from the National Cancer Database Analysis

Upfront surgery is recommended for low-risk esophageal cancer staged T2N0, but preoperative chemotherapy, preoperative chemoradiation or chemoradiation alone is recommended for all others. This study compared overall survival of T2N0 esophageal cancer treated with upfront surgery, neoadjuvant chemoradiation or chemoradiation alone. Results showed that improved overall survival was seen in neoadjuvant chemoradiation patients with tumors greater than 3 cm. Clinical staging for T2N0 esophageal cancer continues to remain highly inaccurate. [Journal of Clinical Oncology 35, 2017 (suppl 4S; abstract 103)]

Propensity Score Matched Analysis of Neoadjuvant Therapy for Resectable Pancreatic Cancer

This study examined the impact of neoadjuvant chemotherapy, neoadjuvant chemoradiation and upfront surgery on survival in pancreatic cancer patients. Results showed that neoadjuvant therapy improves survival in resectable pancreatic cancer patients. Neoadjuvant chemotherapy and neoadjuvant chemoradiation patients demonstrated survival benefit compared to upfront surgery patients, even with adjuvant therapy. [Journal of Clinical Oncology 35, 2017 (suppl 4S; abstract 381)]

Comparative Outcomes of Minimally Invasive and Robotic-assisted Esophagectomy

Minimally invasive esophagectomy has demonstrated superior outcomes compared to open surgical approaches. The robotic technique potentially has additional benefits. This study examined the outcomes of minimally invasive esophagectomy, including robotics. Results showed the robotic technique demonstrated lower blood loss, lower conversion to open surgical approach and lower postoperative complications than other minimally invasive esophagectomy techniques. [Annals of Surgical Oncology 2017, 24 (Suppl. 1S, abstract 414)]

Short- and Long-term Outcomes with Robotic-assisted Esophagectomy

Robotic assistance has the potential to improve the outcomes of minimally invasive esophagectomy. This study showed that overall survival is improved in patients undergoing minimally invasive esophagectomy via robotic or transthoracic surgical approaches. Short- and long-term outcomes with robotic-assisted esophagectomy demonstrated low mortality with superior operative outcomes. [Annals of Surgical Oncology 2017, 24 (Suppl. 1S, abstract 426)]