Patients  
  & Visitors  
  Services &  
  Procedures  
Careers & Employment Volunteers Online Bill Pay Contact Us Concierge 1700 S. Tamiami Trail, 34239 • Phone: (941) 917-9000

Obesity, Exercise May Affect Risk for Key Type of Colon Cancer

Printer Friendly Version Printer Friendly Version
Share

Jun/21/2013

HealthDay News -- Obesity increases a person's risk for a certain type of colorectal cancer, while exercise lowers the risk, according to a new study.

Researchers analyzed data from women in the U.S. Nurses' Health Study and men in the Health Professionals Study to determine if there was a link between weight, exercise and the risk for CTNNB1-positive or CTNNB1-negative colorectal cancer.

CTNNB1 is a molecule implicated in cancer and obesity.

A higher body-mass index, or BMI (a measurement of body fat based on height and weight), was associated with an increased risk of CTNNB1-negative colorectal cancer, while physical activity was associated with a lower risk.

BMI and physical activity had no effect on the risk for CTNNB1-positive colorectal cancer, according to the study appearing Feb. 26 in the journal Cancer Research .

"Our results provide additional evidence for a causal role of obesity and a physically inactive lifestyle in a specific molecular subtype of colorectal cancer," Dr. Shuji Ogino, an associate professor of pathology at Dana-Farber Cancer Institute and an associate professor in the department of epidemiology at Harvard School of Public Health, said in a journal news release.

"If physicians are able to identify individuals who are prone to develop CTNNB1-negative cancer, then it would be possible to strongly recommend physical activity," Ogino added.

The findings also suggest that CTNNB1 could be a potential target for drugs to prevent and treat colorectal cancer in certain patients, Ogino said.

More information
The American Cancer Society has more about colorectal cancer.

Health News Copyright © 2013 HealthDay. All rights reserved.
The information in this article, including reference materials, are provided to you solely for educational or research purposes. Information in reference materials, are not and should not be considered professional health care advice upon which you should rely. Health care information changes rapidly and consequently, information in this article may be out of date. Questions about personal health should always be referred to a physician or other health care professional. 

Reporting Concerns | PRIVACY POLICY | Terms of Service | Online Bill Pay | Mobile Site | Smartphone App
Site optimized for Chrome or Firefox | Copyright © 2014. Sarasota Memorial Health Care System. All rights reserved.